What are the symptoms of adrenal nodules? These cellular changes may be a product of genetics, environmental influences, certain behaviors (such as smoking) or other factors that are not yet fully understood. In a general sense, all cancers – including adrenal cancer – are caused by changes in cellular DNA that allow cells to grow uncontrollably. Some of these disorders include neurofibromatosis type 1, multiple endocrine neoplasia type 2, Li-Fraumeni syndrome and von Hippel-Lindau disease. While researchers are still trying to better understand the specific causes of adrenal gland nodules, studies show that individuals with a personal or family history of certain inherited disorders have a higher risk of developing adrenal masses. A benign (noncancerous) or malignant (cancerous) nodule, also called a tumor or mass, may develop in one of the adrenal glands that sit atop each kidney. The exact causes of adrenal nodules are unclear.
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